In this study we investigated how PFV Gag subnuclear distribution might be regulated.

Conclusions: Varying degrees of PFV seem to be a frequent cause of unilateral congenital cataracts.

For each group, the greatest improvements in NPC and PFV were achieved during the first 4 weeks.

Only the OBVAT group continued to show significant improvements in PFV at weeks 8 and 12.

It is therefore suggested that PFV cores bear at least three separate nuclear localization signals, one in Gag and two in Pol.

This suggests that unilateral PFV may in fact be a bilateral, asymmetric process, but the clinical significance of these subtle findings is not known.

Absence of intercellular spreading in vivo was further confirmed using a sensitive luciferase activity assay based on transactivation of the PFV long terminal repeats.

Conclusions: The rate of improvement is more rapid for clinical signs (NPC and PFV) than for symptoms in children undergoing treatment for CI.

Characteristic features of PFV were found in 75% of group I eyes, in 8% of group II eyes, and in 67% of group III eyes.